Conversion of the major birch pollen allergen, Bet v 1, into two nonanaphylactic T cell epitope-containing fragments: candidates for a novel form of specific immunotherapy.

A novel approach to reduce the anaphylactic activity of allergens is suggested. The strategy makes use of the presence of conformational immunoglobulin E (IgE) epitopes on one of the most common allergens. The three dimensional structure of the major birch pollen allergen, Bet v 1, was disrupted by...

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Main Authors: Vrtala, S, Hirtenlehner, K, Vangelista, L, Pastore, A, Eichler, H G, Sperr, W R, Valent, P, Ebner, C, Kraft, D, Valenta, R
Formato: Artigo
Idioma:Inglês
Publicado: 1997
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC507987/
https://ncbi.nlm.nih.gov/pubmed/9120011
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