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Triethylated chromones with substituted naphthalenes as tubulin inhibitors
Previously synthesized 2-(benzo[b]thiophene-3′-yl)-6,8,8-triethyldesmosdumotin B (1, TEDB-TB) and 2-(naphth-1′-yl)-6,8,8-triethyldesmosdumotin B (2) showed potent activity against multiple human tumor cell lines, including a multidrug-resistant (MDR) subline, by targeting spindle formation and/or th...
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| Udgivet i: | Bioorg Med Chem |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5079804/ https://ncbi.nlm.nih.gov/pubmed/27707623 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.09.062 |
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