Development of a Novel Class of Tubulin Inhibitor from Desmosdumotin B with a Hydroxylated Bicyclic B-Ring

[Image: see text] A series of newly synthesized hydroxylated analogues of triethyldesmosdumotin B (TEDB) with a bicyclic B-ring exhibited a significantly different mode of action for affecting microtubule dynamics and spindle formation but had the same antiproliferative activity spectrum, including...

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Bibliographic Details
Published in:J Med Chem
Main Authors: Nakagawa-Goto, Kyoko, Oda, Akifumi, Hamel, Ernest, Ohkoshi, Emika, Lee, Kuo-Hsiung, Goto, Masuo
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394749/
https://ncbi.nlm.nih.gov/pubmed/25695315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501859j
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