Triethylated chromones with substituted naphthalenes as tubulin inhibitors

Previously synthesized 2-(benzo[b]thiophene-3′-yl)-6,8,8-triethyldesmosdumotin B (1, TEDB-TB) and 2-(naphth-1′-yl)-6,8,8-triethyldesmosdumotin B (2) showed potent activity against multiple human tumor cell lines, including a multidrug-resistant (MDR) subline, by targeting spindle formation and/or th...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Nakagawa-Goto, Kyoko, Taniguchi, Yukako, Watanabe, Yurie, Oda, Akifumi, Ohkoshi, Emika, Hamel, Ernest, Lee, Kuo-Hsiung, Goto, Masuo
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079804/
https://ncbi.nlm.nih.gov/pubmed/27707623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.09.062
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