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Development of a Novel Class of Tubulin Inhibitor from Desmosdumotin B with a Hydroxylated Bicyclic B-Ring

[Image: see text] A series of newly synthesized hydroxylated analogues of triethyldesmosdumotin B (TEDB) with a bicyclic B-ring exhibited a significantly different mode of action for affecting microtubule dynamics and spindle formation but had the same antiproliferative activity spectrum, including...

詳細記述

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書誌詳細
出版年:J Med Chem
主要な著者: Nakagawa-Goto, Kyoko, Oda, Akifumi, Hamel, Ernest, Ohkoshi, Emika, Lee, Kuo-Hsiung, Goto, Masuo
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394749/
https://ncbi.nlm.nih.gov/pubmed/25695315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501859j
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