IL-12/IL-23p40 Is Highly Expressed in Secondary Lymphoid Organs and the CNS during All Stages of EAE, but Its Deletion Does Not Affect Disease Perpetuation

BACKGROUND: Interleukin (IL)-12 and IL-23 are heterodimers that share the p40 subunit, and both cytokines are critical in the differentiation of T helper (Th)1 and Th17 cells, respectively. Th1 and Th17 effector cells have been implicated in the pathogenesis of experimental autoimmune encephalitis (...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cravens, Petra D., Hussain, Rehana Z., Miller-Little, William A., Ben, Li-Hong, Segal, Benjamin M., Herndon, Emily, Stüve, Olaf
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079572/
https://ncbi.nlm.nih.gov/pubmed/27780253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165248
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