TLR3 agonism re‐establishes CNS immune competence during α4‐integrin deficiency

OBJECTIVE: Natalizumab blocks α4‐integrin‐mediated leukocyte migration into the central nervous system (CNS). It diminishes disease activity in multiple sclerosis (MS), but carries a high risk of progressive multifocal encephalopathy (PML), an opportunistic infection with JV virus that may be prompt...

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Detalhes bibliográficos
Publicado no:Ann Clin Transl Neurol
Main Authors: Hussain, Rehana Z., Cravens, Petra C., Doelger, Richard, Dentel, Brianne, Herndon, Emily, Loof, Nicolas, Tsai, Peter, Okuda, Darin T., Racke, Michael K., Stüve, Olaf
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6292184/
https://ncbi.nlm.nih.gov/pubmed/30564621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.664
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