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α4-integrin deficiency in B cells does not affect disease in a T-cell–mediated EAE disease model

OBJECTIVE: The goal of this study was to investigate the role of CD 19(+) B cells within the brain and spinal cord during CNS autoimmunity in a peptide-induced, primarily T-cell–mediated experimental autoimmune encephalomyelitis (EAE) model of MS. We hypothesized that CD19(+) B cells outside the CNS...

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Detalhes bibliográficos
Publicado no:Neurol Neuroimmunol Neuroinflamm
Main Authors: Hussain, Rehana Z., Cravens, Petra D., Miller-Little, William A., Doelger, Richard, Granados, Valerie, Herndon, Emily, Okuda, Darin T., Eagar, Todd N., Stüve, Olaf
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6481229/
https://ncbi.nlm.nih.gov/pubmed/31086806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/NXI.0000000000000563
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