CD11c(+)CD88(+)CD317(+) myeloid cells are critical mediators of persistent CNS autoimmunity

Natalizumab, a humanized monoclonal antibody (mAb) against α4-integrin, reduces the number of dendritic cells (DC) in cerebral perivascular spaces in multiple sclerosis (MS). Selective deletion of α4-integrin in CD11c(+) cells should curtail their migration to the central nervous system (CNS) and am...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Manouchehri, Navid, Hussain, Rehana Z., Cravens, Petra D., Esaulova, Ekaterina, Artyomov, Maxim N., Edelson, Brian T., Wu, Gregory F., Cross, Anne H., Doelger, Richard, Loof, Nicolas, Eagar, Todd N., Forsthuber, Thomas G., Calvier, Laurent, Herz, Joachim, Stüve, Olaf
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8040603/
https://ncbi.nlm.nih.gov/pubmed/33785592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014492118
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