IL-12– and IL-23–modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition

The interleukin (IL)-12p40 family of cytokines plays a critical role in the development of experimental autoimmune encephalomyelitis (EAE). However, the relative contributions of IL-12 and IL-23 to the pathogenic process remain to be elucidated. Here, we show that activation of uncommitted myelin-re...

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Bibliografiske detaljer
Main Authors: Kroenke, Mark A., Carlson, Thaddeus J., Andjelkovic, Anuska V., Segal, Benjamin M.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2008
Fag:
Brief Definitive Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2442630/
https://ncbi.nlm.nih.gov/pubmed/18573909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20080159
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