mTORC2 Signaling Regulates Nox4-Induced Podocyte Depletion in Diabetes

Aim: Podocyte apoptosis is a critical mechanism for excessive loss of urinary albumin that eventuates in kidney fibrosis. Oxidative stress plays a critical role in hyperglycemia-induced glomerular injury. We explored the hypothesis that mammalian target of rapamycin complex 2 (mTORC2) mediates podoc...

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Vydáno v:Antioxid Redox Signal
Hlavní autoři: Eid, Stéphanie, Boutary, Suzan, Braych, Kawthar, Sabra, Ramzi, Massaad, Charbel, Hamdy, Ahmed, Rashid, Awad, Moodad, Sarah, Block, Karen, Gorin, Yves, Abboud, Hanna E., Eid, Assaad A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2016
Témata:
Forum Original Research CommunicationKidney – Part II of II (Y. Gorin, Ed.)
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079418/
https://ncbi.nlm.nih.gov/pubmed/27393154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2015.6562
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