Probenecid and N-Acetylcysteine Prevent Loss of Intracellular Glutathione and Inhibit Neuronal Death after Mechanical Stretch Injury In Vitro

Probenecid and N-acetylcysteine (NAC) can preserve intracellular levels of the vital antioxidant glutathione (GSH) via two distinct biochemical pathways. Probenecid inhibits transporter-mediated GSH efflux and NAC serves as a cysteine donor for GSH synthesis. We hypothesized that probenecid and NAC...

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Bibliographic Details
Published in:J Neurotrauma
Main Authors: Du, Lina, Empey, Philip E., Ji, Jing, Chao, Honglu, Kochanek, Patrick M., Bayır, Hülya, Clark, Robert S.B.
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2016
Subjects:
Short Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079409/
https://ncbi.nlm.nih.gov/pubmed/26830358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/neu.2015.4342
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