Anticancer potential of diarylidenyl piperidone derivatives, HO-4200 and H-4318, in cisplatin resistant primary ovarian cancer

We have previously developed a novel class of bi-functional compounds based on a diarylidenyl-piperidone (DAP) backbone conjugated to an N-hydroxypyrroline (-NOH; a nitroxide precursor) group capable of selectively inhibiting STAT3 activation, translocation, and DNA binding activity. HO-4200 and H-4...

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Détails bibliographiques
Publié dans:Cancer Biol Ther
Auteurs principaux: ElNaggar, Adam C., Saini, Uksha, Naidu, Shan, Wanner, Ross, Sudhakar, Millie, Fowler, John, Nagane, Masaki, Kuppusamy, Periannan, Cohn, David E., Selvendiran, Karuppaiyah
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2016
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5079393/
https://ncbi.nlm.nih.gov/pubmed/27415751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2016.1210733
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