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Exploration of the conformational landscape in pregnane X receptor reveals a new binding pocket
Ligand‐regulated pregnane X receptor (PXR), a member of the nuclear receptor superfamily, plays a central role in xenobiotic metabolism. Despite its critical role in drug metabolism, PXR activation can lead to adverse drug‐drug interactions and early stage metabolism of drugs. Activated PXR can indu...
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| Опубликовано в: : | Protein Sci |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
John Wiley and Sons Inc.
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5079256/ https://ncbi.nlm.nih.gov/pubmed/27515410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3012 |
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