Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity

Most HIV-1 vaccines elicit neutralizing antibodies that are active against highly sensitive (tier-1) viruses or rare cases of vaccine-matched neutralization-resistant (tier-2) viruses, but no vaccine has induced antibodies that can broadly neutralize heterologous tier-2 viruses. In this study, we is...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Bradley, Todd, Trama, Ashley, Tumba, Nancy, Gray, Elin, Lu, Xiaozhi, Madani, Navid, Jahanbakhsh, Fatemeh, Eaton, Amanda, Xia, Shi-Mao, Parks, Robert, Lloyd, Krissey E., Sutherland, Laura L., Scearce, Richard M., Bowman, Cindy M., Barnett, Susan, Abdool-Karim, Salim S., Boyd, Scott D., Melillo, Bruno, Smith, Amos B., Sodroski, Joseph, Kepler, Thomas B., Alam, S.Munir, Gao, Feng, Bonsignori, Mattia, Liao, Hua-Xin, Moody, M. Anthony, Montefiori, David, Santra, Sampa, Morris, Lynn, Haynes, Barton F.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5078591/
https://ncbi.nlm.nih.gov/pubmed/27612593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.08.045
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