Reactive oxygen species induced by therapeutic CD20 antibodies inhibit natural killer cell-mediated antibody-dependent cellular cytotoxicity against primary CLL cells

The antibody-dependent cellular cytotoxicity (ADCC) of natural killer (NK) cells is assumed to contribute to the clinical efficacy of monoclonal antibodies (mAbs) in chronic lymphocytic leukemia (CLL) and other hematopoietic malignancies of B cell origin. We sought to determine whether reactive oxyg...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Werlenius, Olle, Aurelius, Johan, Hallner, Alexander, Akhiani, Ali A., Simpanen, Maria, Martner, Anna, Andersson, Per-Ola, Hellstrand, Kristoffer, Thorén, Fredrik B.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5077995/
https://ncbi.nlm.nih.gov/pubmed/27097113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.8769
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