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Monocytic AML cells inactivate antileukemic lymphocytes: role of NADPH oxidase/gp91(phox) expression and the PARP-1/PAR pathway of apoptosis

Dysfunction of T cells and natural killer (NK) cells has been proposed to determine the course of disease in acute myeloid leukemia (AML), but only limited information is available on the mechanisms of lymphocyte inhibition. We aimed to evaluate to what extent human malignant AML cells use NADPH oxi...

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Bibliografiske detaljer
Main Authors: Aurelius, Johan, Thorén, Fredrik B., Akhiani, Ali A., Brune, Mats, Palmqvist, Lars, Hansson, Markus, Hellstrand, Kristoffer, Martner, Anna
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418695/
https://ncbi.nlm.nih.gov/pubmed/22550344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-11-391722
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