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Monocytic AML cells inactivate antileukemic lymphocytes: role of NADPH oxidase/gp91(phox) expression and the PARP-1/PAR pathway of apoptosis

Dysfunction of T cells and natural killer (NK) cells has been proposed to determine the course of disease in acute myeloid leukemia (AML), but only limited information is available on the mechanisms of lymphocyte inhibition. We aimed to evaluate to what extent human malignant AML cells use NADPH oxi...

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Detalhes bibliográficos
Main Authors: Aurelius, Johan, Thorén, Fredrik B., Akhiani, Ali A., Brune, Mats, Palmqvist, Lars, Hansson, Markus, Hellstrand, Kristoffer, Martner, Anna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418695/
https://ncbi.nlm.nih.gov/pubmed/22550344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-11-391722
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