Exploring Intein Inhibition by Platinum Compounds as an Antimicrobial Strategy

Inteins, self-splicing protein elements, interrupt genes and proteins in many microbes, including the human pathogen Mycobacterium tuberculosis. Using conserved catalytic nucleophiles at their N- and C-terminal splice junctions, inteins are able to excise out of precursor polypeptides. The splicing...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Chan, Hon, Pearson, C. Seth, Green, Cathleen M., Li, Zhong, Zhang, Jing, Belfort, Georges, Shekhtman, Alex, Li, Hongmin, Belfort, Marlene
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5077202/
https://ncbi.nlm.nih.gov/pubmed/27609519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.747824
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