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DUSP1 Maintains IRF1 and Leads to Increased Expression of IRF1-dependent Genes: A MECHANISM PROMOTING GLUCOCORTICOID INSENSITIVITY

Although the mitogen-activated protein kinase (MAPK) phosphatase, DUSP1, mediates dexamethasone-induced repression of MAPKs, 14 of 46 interleukin-1β (IL1B)-induced mRNAs were significantly enhanced by DUSP1 overexpression in pulmonary A549 cells. These include the interferon regulatory factor, IRF1,...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Shah, Suharsh, King, Elizabeth M., Mostafa, Mahmoud M., Altonsy, Mohammed O., Newton, Robert
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076847/
https://ncbi.nlm.nih.gov/pubmed/27551049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.728964
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