Context-dependent Cooperation between Nuclear Factor κB (NF-κB) and the Glucocorticoid Receptor at a TNFAIP3 Intronic Enhancer: A MECHANISM TO MAINTAIN NEGATIVE FEEDBACK CONTROL OF INFLAMMATION

TNF expression is elevated in asthma and other inflammatory airway diseases that are commonly treated with glucocorticoid-based therapies, but the impact of glucocorticoids on negative feedback control of TNF is not well understood. We analyzed the effect of dexamethasone, a potent synthetic glucoco...

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Detalhes bibliográficos
Main Authors: Altonsy, Mohammed O., Sasse, Sarah K., Phang, Tzu L., Gerber, Anthony N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961651/
https://ncbi.nlm.nih.gov/pubmed/24500711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.545178
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