Long-Acting β(2)-Adrenoceptor Agonists Enhance Glucocorticoid Receptor (GR)–Mediated Transcription by Gene-Specific Mechanisms Rather Than Generic Effects via GR

In asthma, the clinical efficacy of inhaled corticosteroids (ICSs) is enhanced by long-acting β(2)-adrenoceptor agonists (LABAs). ICSs, or more accurately, glucocorticoids, promote therapeutically relevant changes in gene expression, and, in primary human bronchial epithelial cells (pHBECs) and airw...

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Veröffentlicht in:Mol Pharmacol
Hauptverfasser: Rider, Christopher F., Altonsy, Mohammed O., Mostafa, Mahmoud M., Shah, Suharsh V., Sasse, Sarah, Manson, Martijn L., Yan, Dong, Kärrman-Mårdh, Carina, Miller-Larsson, Anna, Gerber, Anthony N., Giembycz, Mark A., Newton, Robert
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2018
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7385531/
https://ncbi.nlm.nih.gov/pubmed/29959223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.112755
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