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Lys-63-linked Ubiquitination of γ-Aminobutyric Acid (GABA), Type B1, at Multiple Sites by the E3 Ligase Mind Bomb-2 Targets GABA(B) Receptors to Lysosomal Degradation
GABA(B) receptors are heterodimeric G protein-coupled receptors, which control neuronal excitability by mediating prolonged inhibition. The magnitude of GABA(B) receptor-mediated inhibition essentially depends on the amount of receptors in the plasma membrane. However, the factors regulating cell su...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5076837/ https://ncbi.nlm.nih.gov/pubmed/27573246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.750968 |
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