Ligand-bound Structures and Site-directed Mutagenesis Identify the Acceptor and Secondary Binding Sites of Streptomyces coelicolor Maltosyltransferase GlgE

GlgE is a maltosyltransferase involved in α-glucan biosynthesis in bacteria that has been genetically validated as a target for tuberculosis therapies. Crystals of the Mycobacterium tuberculosis enzyme diffract at low resolution so most structural studies have been with the very similar Streptomyces...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Syson, Karl, Stevenson, Clare E. M., Miah, Farzana, Barclay, J. Elaine, Tang, Minhong, Gorelik, Andrii, Rashid, Abdul M., Lawson, David M., Bornemann, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5076824/
https://ncbi.nlm.nih.gov/pubmed/27531751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.748160
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