Structural Insight into How Streptomyces coelicolor Maltosyl Transferase GlgE Binds α-Maltose 1-Phosphate and Forms a Maltosyl-enzyme Intermediate

[Image: see text] GlgE (EC 2.4.99.16) is an α-maltose 1-phosphate:(1→4)-α-d-glucan 4-α-d-maltosyltransferase of the CAZy glycoside hydrolase 13_3 family. It is the defining enzyme of a bacterial α-glucan biosynthetic pathway and is a genetically validated anti-tuberculosis target. It catalyzes the α...

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Main Authors: Syson, Karl, Stevenson, Clare E. M., Rashid, Abdul M., Saalbach, Gerhard, Tang, Minhong, Tuukkanen, Anne, Svergun, Dmitri I., Withers, Stephen G., Lawson, David M., Bornemann, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4048318/
https://ncbi.nlm.nih.gov/pubmed/24689960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi500183c
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