Structure of Streptomyces Maltosyltransferase GlgE, a Homologue of a Genetically Validated Anti-tuberculosis Target

GlgE is a recently identified (1→4)-α-d-glucan:phosphate α-d-maltosyltransferase involved in α-glucan biosynthesis in bacteria and is a genetically validated anti-tuberculosis drug target. It is a member of the GH13_3 CAZy subfamily for which no structures were previously known. We have solved the s...

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Detalhes bibliográficos
Main Authors: Syson, Karl, Stevenson, Clare E. M., Rejzek, Martin, Fairhurst, Shirley A., Nair, Alap, Bruton, Celia J., Field, Robert A., Chater, Keith F., Lawson, David M., Bornemann, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207445/
https://ncbi.nlm.nih.gov/pubmed/21914799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.279315
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