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Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway
Antiviral response pathways induce interferon by higher-order assembly of signaling complexes called signalosomes. Assembly of the RIG-I signalosome is regulated by K63-linked polyubiquitin chains, which are synthesized by the E3 ubiquitin ligase, TRIM25. We have previously shown that the TRIM25 coi...
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| Publicat a: | Cell Rep |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5076470/ https://ncbi.nlm.nih.gov/pubmed/27425606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.06.070 |
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