Chimeric mice carrying 'regional' targeted deletion of the angiotensin type 1A receptor gene. Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cells.

We have developed chimeric mice carrying 'regional' null mutation of the angiotensin type 1A (AT1A) receptor, the AT1 receptor subtype exclusively present in mouse juxtaglomerular (JG) cells. The chimeric mouse (Agtr1a -/- <--> +/+) is made up of wild-type (Agtr1a +/+) cells or cells...

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Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteurs: Matsusaka, T, Nishimura, H, Utsunomiya, H, Kakuchi, J, Niimura, F, Inagami, T, Fogo, A, Ichikawa, I
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 1996
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Research Article
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC507627/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8878439/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI118988
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