Absence of angiotensin II type 1 receptor in bone marrow–derived cells is detrimental in the evolution of renal fibrosis

We examined the in vivo function of the angiotensin II type 1 receptor (Agtr1) on macrophages in renal fibrosis. Fourteen days after the induction of unilateral ureteral obstruction (UUO), wild-type mice reconstituted with marrow lacking the Agtr1 gene (Agtr1(–/–)) developed more severe interstitial...

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Hlavní autoři: Nishida, Masashi, Fujinaka, Hidehiko, Matsusaka, Taiji, Price, James, Kon, Valentina, Fogo, Agnes B., Davidson, Jeffrey M., Linton, MacRae F., Fazio, Sergio, Homma, Toshio, Yoshida, Hiroaki, Ichikawa, Iekuni
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2002
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC151648/
https://ncbi.nlm.nih.gov/pubmed/12488436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200215045
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