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Absence of angiotensin II type 1 receptor in bone marrow–derived cells is detrimental in the evolution of renal fibrosis

We examined the in vivo function of the angiotensin II type 1 receptor (Agtr1) on macrophages in renal fibrosis. Fourteen days after the induction of unilateral ureteral obstruction (UUO), wild-type mice reconstituted with marrow lacking the Agtr1 gene (Agtr1(–/–)) developed more severe interstitial...

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Udgivet i:J Clin Invest
Principais autores: Nishida, Masashi, Fujinaka, Hidehiko, Matsusaka, Taiji, Price, James, Kon, Valentina, Fogo, Agnes B., Davidson, Jeffrey M., Linton, MacRae F., Fazio, Sergio, Homma, Toshio, Yoshida, Hiroaki, Ichikawa, Iekuni
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2002
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151648/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12488436/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI200215045
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