Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes.

Rodents are the unique species carrying duplicated angiotensin (Ang) type 1 (AT1) receptor genes, Agtr1a and Agtr1b. After separately generating Agtr1a and Agtr1b null mutant mice by gene targeting, we produced double mutant mice homozygous for both Agtr1a and Agtr1b null mutation (Agtr1a-/-; Agtr1b...

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Autores principales: Tsuchida, S, Matsusaka, T, Chen, X, Okubo, S, Niimura, F, Nishimura, H, Fogo, A, Utsunomiya, H, Inagami, T, Ichikawa, I
Formato: Artigo
Lenguaje:Inglês
Publicado: 1998
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC508622/
https://ncbi.nlm.nih.gov/pubmed/9466969
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