Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes.

Rodents are the unique species carrying duplicated angiotensin (Ang) type 1 (AT1) receptor genes, Agtr1a and Agtr1b. After separately generating Agtr1a and Agtr1b null mutant mice by gene targeting, we produced double mutant mice homozygous for both Agtr1a and Agtr1b null mutation (Agtr1a-/-; Agtr1b...

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Main Authors: Tsuchida, S, Matsusaka, T, Chen, X, Okubo, S, Niimura, F, Nishimura, H, Fogo, A, Utsunomiya, H, Inagami, T, Ichikawa, I
Formato: Artigo
Idioma:Inglês
Publicado: 1998
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC508622/
https://ncbi.nlm.nih.gov/pubmed/9466969
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