Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes.

Rodents are the unique species carrying duplicated angiotensin (Ang) type 1 (AT1) receptor genes, Agtr1a and Agtr1b. After separately generating Agtr1a and Agtr1b null mutant mice by gene targeting, we produced double mutant mice homozygous for both Agtr1a and Agtr1b null mutation (Agtr1a-/-; Agtr1b...

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Bibliografski detalji
Izdano u:J Clin Invest
Glavni autori: Tsuchida, S, Matsusaka, T, Chen, X, Okubo, S, Niimura, F, Nishimura, H, Fogo, A, Utsunomiya, H, Inagami, T, Ichikawa, I
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 1998
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508622/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9466969/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI1899
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