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Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms

The Cytolethal Distending Toxin (CDT), produced by many bacteria, has been associated with various diseases including cancer. CDT induces DNA double-strand breaks (DSBs), leading to cell death or mutagenesis if misrepaired. At low doses of CDT, other DNA lesions precede replication-dependent DSB for...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Bezine, Elisabeth, Malaisé, Yann, Loeuillet, Aurore, Chevalier, Marianne, Boutet-Robinet, Elisa, Salles, Bernard, Mirey, Gladys, Vignard, Julien
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075911/
https://ncbi.nlm.nih.gov/pubmed/27775089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36022
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