Genotoxicity of Cytolethal Distending Toxin (CDT) on Isogenic Human Colorectal Cell Lines: Potential Promoting Effects for Colorectal Carcinogenesis

The composition of the human microbiota influences tumorigenesis, notably in colorectal cancer (CRC). Pathogenic Escherichia coli possesses a variety of virulent factors, among them the Cytolethal Distending Toxin (CDT). CDT displays dual DNase and phosphatase activities and induces DNA double stran...

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Bibliographic Details
Published in:Front Cell Infect Microbiol
Main Authors: Graillot, Vanessa, Dormoy, Inge, Dupuy, Jacques, Shay, Jerry W., Huc, Laurence, Mirey, Gladys, Vignard, Julien
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2016
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4803749/
https://ncbi.nlm.nih.gov/pubmed/27047802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2016.00034
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