The Dipole Potential Modifies the Clustering and Ligand Binding Affinity of ErbB Proteins and Their Signaling Efficiency

Although activation of the ErbB family of receptor tyrosine kinases (ErbB1-4) is driven by oligomerization mediated by intermolecular interactions between the extracellular, the kinase and the transmembrane domains, the transmembrane domain has been largely neglected in this regard. The largest cont...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Kovács, Tamás, Batta, Gyula, Hajdu, Tímea, Szabó, Ágnes, Váradi, Tímea, Zákány, Florina, Csomós, István, Szöllősi, János, Nagy, Peter
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2016
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075772/
https://ncbi.nlm.nih.gov/pubmed/27775011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35850
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