Comprehensive Model for Epidermal Growth Factor Receptor Ligand Binding Involving Conformational States of the Extracellular and the Kinase Domains

The epidermal growth factor (EGF) receptor (EGFR) undergoes ligand-dependent dimerization to initiate transmembrane signaling. Although crystallographic structures of the extracellular and kinase domains are available, ligand binding has not been quantitatively analyzed taking the influence of both...

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Detalles Bibliográficos
Publicado en:Front Cell Dev Biol
Main Authors: Hajdu, Tímea, Váradi, Tímea, Rebenku, István, Kovács, Tamás, Szöllösi, János, Nagy, Peter
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020
Assuntos:
Cell and Developmental Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7431817/
https://ncbi.nlm.nih.gov/pubmed/32850868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.00776
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