Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay

Middle East respiratory syndrome (MERS) is an emerging infectious disease associated with a relatively high mortality rate of approximately 40%. MERS is caused by MERS coronavirus (MERS-CoV) infection, and no specific drugs or vaccines are currently available to prevent MERS-CoV infection. MERS-CoV...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Yamamoto, Mizuki, Matsuyama, Shutoku, Li, Xiao, Takeda, Makoto, Kawaguchi, Yasushi, Inoue, Jun-ichiro, Matsuda, Zene
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5075056/
https://ncbi.nlm.nih.gov/pubmed/27550352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01043-16
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