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Combined administration of buprenorphine and naltrexone produces antidepressant-like effects in mice
Opiates have been used historically for the treatment of depression. Renewed interest in the use of opiates as antidepressants has focussed on the development of kappa opioid receptor (κ-receptor) antagonists. Buprenorphine acts as a partial μ-opioid receptor agonist and a κ-receptor antagonist. By...
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| Publicado no: | J Psychopharmacol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5075030/ https://ncbi.nlm.nih.gov/pubmed/26045511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0269881115586937 |
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