Oral administration of inosine produces antidepressant-like effects in mice

Inosine, a breakdown product of adenosine, has recently been shown to exert immunomodulatory and neuroprotective effects. We show here that the oral administration of inosine has antidepressant-like effects in two animal models. Inosine significantly enhanced neurite outgrowth and viability of prima...

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Main Authors: Muto, Junko, Lee, Hosung, Lee, Hyunjin, Uwaya, Akemi, Park, Jonghyuk, Nakajima, Sanae, Nagata, Kazufumi, Ohno, Makoto, Ohsawa, Ikuroh, Mikami, Toshio
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935199/
https://ncbi.nlm.nih.gov/pubmed/24569499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep04199
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