Basic fibroblast growth factor induces matrix metalloproteinase-13 via ERK MAP kinase-altered phosphorylation and sumoylation of Elk-1 in human adult articular chondrocytes

Degradation of the extracellular matrix (ECM) by matrix metalloproteinases (MMPs) and release of basic fibroblast growth factor (bFGF) are principal aspects of the pathology of osteoarthritis (OA). ECM disruption leads to bFGF release, which activates the extracellular signal-regulated kinase/mitoge...

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Publicat a:Open Access Rheumatol
Autors principals: Im, Hee-Jeong, Sharrocks, Andrew D, Lin, Xia, Yan, Dongyao, Kim, Jaesung, van Wijnen, Andre J, Hipskind, Robert A
Format: Artigo
Idioma:Inglês
Publicat: Dove Medical Press 2009
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074718/
https://ncbi.nlm.nih.gov/pubmed/27789988
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