Basic Fibroblast Growth Factor Stimulates Matrix Metalloproteinase-13 via the Molecular Cross-talk between the Mitogen-activated Protein Kinases and Protein Kinase Cδ Pathways in Human Adult Articular Chondrocytes

Excessive release of basic fibroblast growth factor (bFGF) during loading and/or injury of the cartilage matrix may contribute to the onset or progression of osteoarthritis. This pathological role may be related to the ability of bFGF to decrease proteoglycan synthesis and to antagonize the activity...

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Bibliographic Details
Main Authors: Im, Hee-Jeong, Muddasani, Prasuna, Natarajan, Viswanathan, Schmid, Thomas M., Block, Joel A., Davis, Francesca, van Wijnen, Andre J., Loeser, Richard F.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2895271/
https://ncbi.nlm.nih.gov/pubmed/17311929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M609040200
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