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Fibroblast Growth Factor–2 Promotes Catabolism Via FGFR1–Ras–Raf–MEK1/2–ERK1/2 Axis That Coordinates With the PKCδ Pathway in Human Articular Chondrocytes

Fibroblast growth factor 2 (FGF-2) has been found to play an anti-anabolic and/or a catabolic role in adult human articular cartilage via regulation of multiple signaling pathways. Upon FGF-2 stimulation, a molecular crosstalk between the mitogen activated protein kinase (MAPK) and protein kinase C...

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Dettagli Bibliografici
Autori principali: Yan, Dongyao, Chen, Di, Im, Hee-Jeong
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3684697/
https://ncbi.nlm.nih.gov/pubmed/22488450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.24160
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