Basic fibroblast growth factor induces matrix metalloproteinase-13 via ERK MAP kinase-altered phosphorylation and sumoylation of Elk-1 in human adult articular chondrocytes

Degradation of the extracellular matrix (ECM) by matrix metalloproteinases (MMPs) and release of basic fibroblast growth factor (bFGF) are principal aspects of the pathology of osteoarthritis (OA). ECM disruption leads to bFGF release, which activates the extracellular signal-regulated kinase/mitoge...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Open Access Rheumatol
Main Authors: Im, Hee-Jeong, Sharrocks, Andrew D, Lin, Xia, Yan, Dongyao, Kim, Jaesung, van Wijnen, Andre J, Hipskind, Robert A
Format: Artigo
Jezik:Inglês
Izdano: Dove Medical Press 2009
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074718/
https://ncbi.nlm.nih.gov/pubmed/27789988
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