Basic fibroblast growth factor induces matrix metalloproteinase-13 via ERK MAP kinase-altered phosphorylation and sumoylation of Elk-1 in human adult articular chondrocytes

Degradation of the extracellular matrix (ECM) by matrix metalloproteinases (MMPs) and release of basic fibroblast growth factor (bFGF) are principal aspects of the pathology of osteoarthritis (OA). ECM disruption leads to bFGF release, which activates the extracellular signal-regulated kinase/mitoge...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Open Access Rheumatol
Egile Nagusiak: Im, Hee-Jeong, Sharrocks, Andrew D, Lin, Xia, Yan, Dongyao, Kim, Jaesung, van Wijnen, Andre J, Hipskind, Robert A
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Dove Medical Press 2009
Gaiak:
Original Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074718/
https://ncbi.nlm.nih.gov/pubmed/27789988
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