IRGB10 liberates bacterial ligands for sensing by the AIM2 and caspase-11–NLRP3 inflammasomes

The inflammasome is an intracellular signaling complex, which on recognition of pathogens and physiological aberration, drives activation of caspase-1, pyroptosis, and the release of the pro-inflammatory cytokines IL-1β and IL-18. Bacterial ligands must secure entry into the cytoplasm to activate in...

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Publicado no:Cell
Principais autores: Man, Si Ming, Karki, Rajendra, Sasai, Miwa, Place, David E., Kesavardhana, Sannula, Temirov, Jamshid, Frase, Sharon, Zhu, Qifan, Malireddi, R.K. Subbarao, Kuriakose, Teneema, Peters, Jennifer L., Neale, Geoffrey, Brown, Scott A., Yamamoto, Masahiro, Kanneganti, Thirumala-Devi
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074697/
https://ncbi.nlm.nih.gov/pubmed/27693356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.09.012
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