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Molecular basis of the human dihydropyrimidine dehydrogenase deficiency and 5-fluorouracil toxicity.

Dihydropyrimidine dehydrogenase (DPD) deficiency constitutes an inborn error in pyrimidine metabolism associated with thymine-uraciluria in pediatric patients and an increased risk of toxicity in cancer patients receiving 5-fluorouracil (5-FU) treatment. The molecular basis for DPD deficiency in a B...

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Detalhes bibliográficos
Main Authors: Wei, X, McLeod, H L, McMurrough, J, Gonzalez, F J, Fernandez-Salguero, P
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC507468/
https://ncbi.nlm.nih.gov/pubmed/8698850
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