Long-Range Signaling in MutS and MSH Homologs via Switching of Dynamic Communication Pathways

Allostery is conformation regulation by propagating a signal from one site to another distal site. This study focuses on the long-range communication in DNA mismatch repair proteins MutS and its homologs where intramolecular signaling has to travel over 70 Å to couple lesion detection to ATPase acti...

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Опубликовано в: :PLoS Comput Biol
Главные авторы: Wang, Beibei, Francis, Joshua, Sharma, Monika, Law, Sean M., Predeus, Alexander V., Feig, Michael
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2016
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074593/
https://ncbi.nlm.nih.gov/pubmed/27768684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005159
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