Dexmedetomidine Acts via the JAK2/STAT3 Pathway to Attenuate Isoflurane-Induced Neurocognitive Deficits in Senile Mice

BACKGROUND: Previous studies showed that isoflurane-induced cognitive deficits could be alleviated by dexmedetomidine in young animal subjects. In the current study, we examine whether dexmedetomidine could also alleviate isoflurane-induced cognitive deficits in senile animals. METHODS: Senile male...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Si, Yanna, Zhang, Yuan, Han, Liu, Chen, Lihai, Xu, Yajie, Sun, Fan, Ji, Muhuo, Yang, Jianjun, Bao, Hongguang
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074497/
https://ncbi.nlm.nih.gov/pubmed/27768775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0164763
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