Long-Term Reduction of Kappa Opioid Receptor Function by the Biased Ligand, Norbinaltorphimine, Requires c-Jun N-Terminal Kinase Activity and New Protein Synthesis in Peripheral Sensory Neurons

A single administration of the κ opioid receptor (KOR) antagonist, norbinaltorphimine (norBNI), produces long-term reduction in KOR function in heterologous expression systems and brain that is mediated by activation of c-Jun N-terminal kinase (JNK). In this study, we examined the long-term effects...

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Bibliografiska uppgifter
I publikationen:J Pharmacol Exp Ther
Huvudupphovsmän: Jamshidi, Raehannah J., Sullivan, Laura C., Jacobs, Blaine A., Chavera, Teresa A., Berg, Kelly A., Clarke, William P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Pharmacology and Experimental Therapeutics 2016
Ämnen:
Cellular and Molecular
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074480/
https://ncbi.nlm.nih.gov/pubmed/27605628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.235184
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