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A backbone amide protecting group for overcoming difficult sequences and suppressing aspartimide formation

A backbone amide bond protecting group, 2‐hydroxy‐4‐methoxy‐5‐nitrobenzyl (Hmnb), improved the synthesis of aggregation and aspartimide‐prone peptides. Introduction of Hmnb is automated and carried out during peptide assembly by addition of 4‐methoxy‐5‐nitrosalicylaldehyde to the peptidyl‐resin and...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Pept Sci
Prif Awduron: Abdel‐Aal, Abu‐Baker M., Papageorgiou, George, Raz, Richard, Quibell, Martin, Burlina, Fabienne, Offer, John
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074248/
https://ncbi.nlm.nih.gov/pubmed/27086749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psc.2877
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